To explore the early diagnostic value of ischemic modified albumin (IMA), heart-type fatty acid binding protein (H-FABP), soluble growth stimulation expression gene 2 protein (sST2) and GRACE score for acute coronary syndrome (ACS).

One hundred patients with ACS treated from July 2021 to February 2022 were enrolled in this study. Serum IMA and H-FABP concentrations were measured by latex-enhanced immunodeficiency, and serum sST2 concentration was measured by immunofluorescence dry quantification. The levels of serum IMA, H-FABP and sST2 in the three groups were compared, and the patients were divided into low-risk group, medium-risk group and high-risk group according to the risk stratification of the Global Registry of Acute Coronary Events (GRACE). The relationship between GRACE score and the three indicators was analyzed. The receiver operating characteristic curve (ROC) was used to evaluate the specificity and sensitivity of each index, and to analyze the relationship between the three indexes and ACS.

The serum levels of IMA, H-FABP and sST2 in the observation group were significantly higher than those in the control group (P＜0.05). There was no significant difference in serum IMA, H-FABP and sST2 levels were compared among three groups, and it was elevated in the low-risk state. Correlation analysis showed that serum IMA, H-FABP and sST2 levels were not correlated with GRACE score (r=-0.028, P=0.785; r=-0.011, P=0.910; r=-0.046, P=0.65). The ROC curve showed that IMA, H-FABP and sST2 had good specificity (89%~96%), but only general sensitivity (54%~76%). The combined detection of the three indexes had a better auxiliary diagnostic efficacy for ACS (AUC=0.962, sensitivity=92%, specificity=94%), which was significantly higher than the individual detection of each index.

The serum levels of IMA, H-FABP and sST2 are abnormally elevated in patients with early ACS, and they are not correlated with GRACE score. However, the combination of the three methods can improve the diagnostic efficiency of ACS, and has certain significance for the early diagnosis of ACS patients.