To analyze the main epidemic status and risk factors of chronic diseases in Liwan District of Guangzhou, and to provide basis for the formulation of measures to prevent chronic diseases.

In 2018, a multi-stage stratified cluster sampling method was used to conduct an epidemiological survey among 3831 permanent residents over 18 years old in Liwan District of Guangzhou, including personal questionnaire and physical examination.

In Liwan District of Guangzhou, the total prevalence of chronic diseases in residents over 18 years old was 52.7%, and the sequence of chronic diseases was other chronic diseases, hypertension, hyperlipidemia, diabetes, allergic diseases, kidney diseases, chronic obstructive pulmonary disease, coronary heart disease, Alzheimer's disease and stroke. Among them, the prevalence rate of males (55.5%) was significantly higher than that of females (51.0%) (P＜0.05). The prevalence of major chronic diseases in ≥65 years old population was significantly higher than that in the general surveillance population (P＜0.05). Multivariate Logistic regression analysis showed that the influence factors for hypertension were family history, salt control, poor sleep quality, overweight or obesity. The influence factors for diabetes were overweight or obesity. The influence factors for hyperlipidemia were family history, salt control, overweight or obesity. Overweight or obesity is a common risk factor, and salt control is a protective factor.

The prevalence of chronic diseases in Liwan District of Guangzhou is still at a high level, and the main epidemic diseases are hypertension, hyperlipidemia and diabetes, and overweight or obesity are common risk factors. Comprehensive prevention and control measures and strategies should be formulated according to the local epidemic characteristics, focusing on obese people, so as to reduce the occurrence and prevalence of chronic diseases in Guangzhou.