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Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2017, Vol. 05 ›› Issue (02): 81-88. doi: 10.3877/cma.j.issn.2095-5820.2017.02.005

Special Issue:

• Symposium • Previous Articles     Next Articles

Diagnostic application of flow cytometry in mature lymphoid neoplasm

Hui Wang1,(), Aixian Wang1, Junyi Zhen1, Xueying Wu1, Man Chen1, Meiwei Gong1, Yuzhu Song1, Guoxin Wei1, Qing Du1   

  1. 1. Department of Pathology and Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Sanhe 065201, China
  • Received:2017-01-23 Online:2017-05-28 Published:2017-05-28
  • Contact: Hui Wang
  • About author:
    Corresponding author: Wang Hui, Email:

Abstract:

Flow cytometry (FCM) uses flow cytometer to detect the expression of immunological markers on cells based on antigen-antibody binding and laser activating fluorescence. FCM plays a very important role in clinical diagnosis especially in acute leukemia diagnosis and subclassification. However, due to the difficulty in acquiring the sample and the existence of normal lymphocytes in the background, its application and improvement should be further strengthened in the diagnosis of mature lymphoid neoplasm. This paper focuses on the similarity and differences between FCM and pathology immunohistology, immune makers in lymphoma detection, immunophenotypic features of common mature lymphoid neoplasm, common issues and key points in FCM detection, to study the diagnostic application of flow cytometry in mature lymphoid neoplasm. This will help clinicians understand this technic, and make a correct diagnosis by FCM combining with pathology.

Key words: Flow cytometry, Mature lymphoid, Neoplasm, Diagnosis

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