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Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2022, Vol. 10 ›› Issue (02): 95-100. doi: 10.3877/cma.j.issn.2095-5820.2022.02.005

• Experiment Researchs • Previous Articles     Next Articles

Explore the effective alarm index of low mean volume of red blood cells affecting false increase of PLT

Meishuang Lin1,(), Huidi Sun1   

  1. 1. The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Guangdong 510260, China
  • Received:2021-06-11 Online:2022-05-28 Published:2022-07-14
  • Contact: Meishuang Lin

Abstract:

Objective

To analyze and compare the effect of low MCV specimens on the platelet count related indicators of the resistance method of Sysmex XN-2000 hematology analyzer, and search for the effective alarm indicators of PLT false increase caused by low MCV.

Methods

The PLT results of different MCV samples were collected by Sysmex XN-2000 hematology analyzer fluorescence method and resistance. The fluorescence method and resistance method difference of platelet detection (ΔPLT) under different grouping conditions were compared, and the correlation of cell parameters, cell histogram morphology and instrument alarm information with platelet difference (ΔPLT) was analyzed.

Results

ΔPLT in MCV<80 fl group is higher than MCV≥80 fl group (P<0.05); ΔPLT in MCV<60 fl group is higher than MCV≥60 fl group (P<0.05); when PLT-Ⅰ is between 150×109/L and 600×109/L, ΔPLT increases with the value increases (P<0.05); PDW, MCHC, RDW-SD and ΔPLT have a certain correlation (P<0.05), but R2 is less than 0.95. The ratio of "Tail is not close to the abscissa" and "the tail is raised and forms the second peak" two kinds of platelet histogram phenomenon, red blood cell histogram "peak left shift" phenomenon, instrument alarm message "platelet abnormal distribution (PLT Abn Distribution)","Thrombocytosis","Anisocytosis","Fragments" and "Microcytosis" account was lower in ΔPLT≥100×109/L group than ΔPLT<100×109/L group (P<0.01).

Conclusions

Low MCV affected the PLT-Ⅰ results by the Sysmex XN-2000 hematologyanalyzer. The lower the MCV, the greater influence of PLT-I. When the PLT-Ⅰ≥70×109/L, low MCV has greater influence on PLT-Ⅰ with the increase of PLT-Ⅰ. Combining the platelet histogram, the platelet instrument alarm message, the red blood cell histogram and the red blood cell instrument alarm message are helpful to judge the reliability of the resistance method of Sysmex XN-2000 hematologyanalyzer. It provides a comprehensive reference index and judgment basis for the timely discovery of low MCV affecting platelet count in clinical work.

Key words: Etythrocytes, Platelet count, Flow cytometry, Electric impedance

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