Reactive functional groups decorate fluoride upconversion nanoparticles NaYF4: Yb, Er with silica coating

doi:10.3877/cma.j.issn.2095-5820.2020.04.009

Chinese Journal of Clinical Laboratory Management(Electronic Edition) ›› 2020, Vol. 08 ›› Issue (04): 228-232. doi: 10.3877/cma.j.issn.2095-5820.2020.04.009

Special Issue: ；

• Clinical Research • Previous Articles Next Articles

Reactive functional groups decorate fluoride upconversion nanoparticles NaYF₄: Yb, Er with silica coating

Xinqiang Xu¹, Xuesong Li¹, Tianxing Ji², Meng Lei³, Qiang Zhou²^,^†()

^1. Clinical Laboratory, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, GuangZhou 510405, China
^2. Clinical Laboratory, The Second Affiliated Hospital of Guangzhou Medical University, GuangZhou 510260, China
^3. Clinical Laboratory, Yichun People’s Hospital, Yichun Guangdong 336000, China

Received:2020-08-08 Online:2020-11-28 Published:2020-11-28
Contact: Qiang Zhou
About author:
Corresponding author: Zhou Qiang, Email: qiangzhou70@163.com

Abstract

Abstract:

Objective

To modify the surface of nanoparticles for biological application.

Methods

NaYF₄: Yb, Er nanoparticles were synthesized by thermal decomposition method, then a thin layer of SiO₂ was coated on the surface of above nanoparticles by microemulsion method and epoxy group was also modified on the surface. In addition, the nanoparticles morphology, luminescence properties and surface properties were characterized by transmission electron microscopy (TEM), fluorescence spectroscopy and fourier infrared spectrum analyzer(FT-IR),respectively.

Results

Uniform-size and hexagonal-phase NaYF₄: Yb, Er were synthesized by thermal decomposition method. Silica-coated NaYF₄: Yb, Er nanoparticles still had strong luminescence properties, and nanoparticles could be further modified with epoxide group.

Conclusion

The fluoride upconversion nanoparticle with strong luminescence properties and stability after surface modification could be used as a new biological fluorescent marker in the biomedical field.

Key words: NaYF₄:Yb, Er, Thermal decomposition method, Silica coated, Epoxy group

Xinqiang Xu, Xuesong Li, Tianxing Ji, Meng Lei, Qiang Zhou. Reactive functional groups decorate fluoride upconversion nanoparticles NaYF₄: Yb, Er with silica coating[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2020, 08(04): 228-232.

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Figures/Tables 5

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