Analysis of urine crystals in 3 cases of overdose of amoxicillin-clavulanate potassium Lin Wenjun. Laboratory Department, Huangyan District Urban Community Health Service Center of Taizhou, Taizhou Zhejiang 318020, China

doi:10.3877/cma.j.issn.2095-5820.2024.01.010

Abstract

Abstract:

Objective

To help inspectors to detect the crystals of the drug early in daily testing and provide a reference for clinical safety medication by exploring the characteristics of amoxicillin-clavulanate crystals in urine.

Methods

The morphological characteristics of amoxicillin-clavulanate crystals were observed and the physicochemical tests were carried out. Combined with relevant domestic and foreign literatures, other crystals with similar morphology in urine were identified and distinguished.

Results

Amoxicillin-clavulanate potassium crystals were confirmed in the urine of 3 patients.

Conclusions

The crystal of amoxicillin-clavulanate potassium is more likely to precipitate from the urine of patients with overdose of amoxicillin-clavulanate potassium. When similar needle-shaped crystals are found, the inspector should consider the adverse reactions of amoxicillin-clavulanate potassium, communicate with the clinician in time, ask about the medication, and prompt clinicians to pay attention to the dose of medication to prevent patients from renal injuries due to excessive medication.

Key words: urinary tract infection, amoxicillin-clavulanate potassium, drug crystals, adverse drug reactions

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URL: https://zhlcsysgldzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-5820.2024.01.010

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Figures/Tables 4

References 8

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结晶程度	25 ℃放置2 h的外观	4 ℃放置2 h的外观	RCF400×g离心5 min后沉渣涂片	光学显微镜下形态
轻度	清晰	微浑	无细颗粒	无色、散在、细针样结晶
重度	浑浊	浑浊、白色团块状沉淀	有细沙状颗粒	褐色、细针形结晶聚集呈蝴蝶状、扫帚状

结晶程度	25 ℃放置2 h的外观	4 ℃放置2 h的外观	RCF400×g离心5 min后沉渣涂片	光学显微镜下形态
轻度	清晰	微浑	无细颗粒	无色、散在、细针样结晶
重度	浑浊	浑浊、白色团块状沉淀	有细沙状颗粒	褐色、细针形结晶聚集呈蝴蝶状、扫帚状

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