The relevant documents of clinical laboratory biosafety are rich in connotation and involved in a wide range. The correct interpretation of these safety documents is the basis of laboratory biosafety management. To interpret the laboratory biosafety documents, we must first understand the classification of biosafety related documents, distinguish the file hierarchy and subject categories, We should comprehensively interpret these safety documents based on the principle of grasping the main points, combining actual and practical principles, classifying and evidence-based principles, the principle of advancing with times, and complying with basic and comprehensive interpretation principles, and then then do a good job in laboratory biosafety.